The Search for the Legacy of the USPHS Syphilis Study at Tuskegee is a collection of essays from experts in a variety of fields seeking to redefine the legacy of the infamous Tuskegee Syphilis Study. The essayists place the legacy of the study within the evolution of racial and ethnic relations in the United States. Contributors include two leading historians on the study, two former United States Surgeons General, and other prominent scholars from a wide range of fields.

Self‐renewal and differentiation of stem cells are tightly regulated processes subject to intrinsic and extrinsic signals. Molecular chaperones and co‐chaperones, especially heat shock proteins (Hsp), are ubiquitous molecules involved in the modulation of protein conformational and complexation states. The function of Hsp, which are typically associated with stress response and tolerance, is well characterized in differentiated cells, while their role in stem cells remains unclear. It appears that embryonic stem cells exhibit increased stress tolerance and concomitant high levels of chaperone (...) expression. This review critically evaluates stem cell research from a molecular chaperone perspective. Furthermore, we propose a model of chaperone‐modulated self‐renewal in mouse embryonic stem cells. (shrink)

Growing literature has linked attention bias variability to the experience and treatment of posttraumatic stress disorder. Unlike assessments of attention bias in only one direction, A...

Heidegger, Sartre and the later existentialist philosophers inherited a world, it has been said, from which "God is absent". Contemporary philosophy begins in the momentous questioning of the Christian experience by such nineteenth-century figures as Nietzsche and Dosteyevsky. But if existentialism is in some respects a beginning-again, it is in other respects linked to the classical world out of which Christianity arose and to certain themes in the writings of ancient and medieval Christians. Renewal and innovation converge. Addressing themselves to (...) the general reader, the three author-philosophers consider both the contemporary and the perennial. [Book jacket]. (shrink)

Heidegger, Sartre and the later existentialist philosophers inherited a world, it has been said, from which "God is absent". Contemporary philosophy begins in the momentous questioning of the Christian experience by such nineteenth-century figures as Nietzsche and Dosteyevsky. But if existentialism is in some respects a beginning-again, it is in other respects linked to the classical world out of which Christianity arose and to certain themes in the writings of ancient and medieval Christians. Renewal and innovation converge. Addressing themselves to (...) the general reader, the three author-philosophers consider both the contemporary and the perennial. [Book jacket]. (shrink)

There can be little doubt, I think, that the quality and texture of recent scientific and philosophical thought mark a greater break with the past than any innovations such as were introduced by a Gallileo or a Newton, a Descartes or a Kant. The switch over from the logicality and essential rationality of these men to the irrationalisms, the anti-intellectualisms, and the new logics of the moderns, is not at all on the same footing as that deepening of our concepts (...) of knowledge and reality which we associate with the masters of thought, more particularly with the critical philosophy of Kant. Strong and significant as these earlier changes were, they marked but the onward strides of an art of thinking which remained in its essence the same in spite of them. But the thinkers in the public eye to-day are exploring in unknown regions, and it may turn out that they have got beyond their depth. Whatever their fate, it seems undeniable that the experiments that they have made and are making constitute, at points at least, and for the time being, a veritable revolution. (shrink)